Best to include what exactly is, or is not happening, and relevant details. Eg- Does it launch? What sort of crash, to desktop, black screen, BSOD? What fixes have you already tried and what are your system specifications including brand and model graphics card (even though you can run any other game). - Have you run Steams 'Verify Integrity of Game Cache' tool? ( R/click on title in your Steam Library > Properties > Local Files ) - Have you tried disabling DEP, or making an exception for GTA5 (this is one of those things that seems to help some, while others don't need it )?